The cholesterol-lowering medication, Crestor, may be linked to a number of major side effects in patients taking the medication to treat their high or borderline high cholesterol. Crestor (rosuvastatin) belongs to a group of drugs called HMG CoA reductase inhibitors, or statins, which are used to lower cholesterol and triglycerides, or types of fat, in the blood. Cholesterol medications like Crestor lower the levels of bad cholesterol (low-density lipoprotein) and increase the levels of good cholesterol (high-density lipoprotein) in the blood. Crestor is also used to lower the risk of stroke, heart attack and other heart problems in people with diabetes and coronary heart disease. Crestor was approved by the FDA in 2003 and is currently manufactured by AstraZeneca Pharmaceuticals.
AstraZeneza marketed Crestor to consumers as the newest and the strongest of the already powerful statins on the U.S. market. Unfortunately, Crestor side effect information shows that the dosage requirements for Crestor are much higher than the recommended doses for other cholesterol drugs, including Zocor and Lipitor, which studies show may already be more than most consumers need. In addition, Crestor side effect studies indicate that Crestor may be associated with severe and potentially fatal side effects, which may actually outweigh the possible benefits of the treatment. If you or a loved one has suffered from a potential Crestor side effect, contact an experienced Crestor attorney to discuss your legal options.
Millions of Americans are affected by high cholesterol, which can lead to an increased risk of serious complication, including arterial disease. Unfortunately, one of the most popular cholesterol drugs, Crestor, may be associated with side effects so severe that they may be even more dangerous than those linked to high cholesterol. According to Crestor side effect studies and clinical trials, the drug may be associated with life-threatening side effects like:
Researchers at the Tufts-New England Medical Center compared the safety profiles of the three most commonly used statins and discovered that Crestor has the poorest safety profile. The most serious reactions associated with Crestor included kidney damage and muscle damage (rhabdomyolysis), which frequently resulted in patients requiring hospitalization. This study, published in Circulation: Journal of the American Heart Association, raised serious concerns about the safety of Crestor at the range of doses currently used in the general population. According to researchers involved in this study, healthcare professionals should consider other statins besides Crestor as first-line therapy and should closely monitor patients for adverse events if the decision to use Crestor is made.
According to researchers, most patients with elevated cholesterol have only mild or moderate elevations, which require only modest doses of statin drugs like Crestor. However, the standard starting dosage for Crestor is so high that AstraZeneca claims the drug can reduce bad cholesterol by 46-52%, when most patients with high cholesterol require only a 20-30% reduction. The strength of even the standard doses of Crestor exposes patients to extremely high levels of the statin drug, which may be unnecessary in treating the condition successfully and may lead to the unnecessary development of serious side effects. In 2005, the FDA issued a public health advisory warning patients and healthcare providers about the risk of kidney failure and rhabdomyolysis, or serious muscle damage, in patients taking statin drugs like Crestor. In response to the potential adverse effects of Crestor, the FDA required a Crestor label change to include important information on the safe use of Crestor to reduce the risk of rhabdomyolysis.
Despite this potential for causing serious harm, the FDA approved a wider use of Crestor in 2010, allowing the drug to be marketed to patients with only slightly elevated cholesterol levels, a population previously considered at low risk for developing cardiovascular disease. This new FDA approval was influenced by a recent study which evaluated patients with normal or slightly elevated cholesterol levels, but who had an elevated C-reactive protein level, which is considered a marker for an increased risk of cardiovascular disease. This study was sponsored and financially supported by Crestor maker AstraZeneca, after it was previously rejected by the National Institutes of Health and at least two other organizations.
The Crestor warning issued by the FDA is part of an ongoing effort to adequately inform consumers of the potential side effects associated with the statin, Crestor. Unfortunately, with the FDA approval of a new indication for Crestor, an even larger population of patients is exposed to Crestor, which may be linked to life-threatening side effects. If you or a loved one has suffered from an alleged Crestor side effect, contact a Crestor attorney to discuss the benefits of filing a Crestor lawsuit against AstraZeneca. The goal of Crestor lawsuits is to seek financial compensation for your injuries and medical expenses, as well as the pain and suffering endured by you and your family. Drug companies like AstraZeneca are responsible for the safety and effectiveness of their drugs, and should be held accountable for any adverse side effects sustained by consumers of their products. Unfortunately, this isn't always the case. With the help of an experienced Crestor lawyer, victims of potential Crestor side effects can protect themselves from further harm and hold the allegedly negligent pharmaceutical company liable for the side effects of their dangerous drug.
Side Effects RX is an informational website that educates consumers on side effects that could have been caused by drugs and medical devices. This website has no relationship with any of the aforementioned drugs, pharmaceutical companies or medical device companies. SideEffectsRx.com was not written by medical professionals and should not be mistaken for medical advice. The purpose of this site is to inform consumers of the potential for side effects in certain drugs and medical devices. *This is a Consumer Justice Foundation website. We are not attorneys. Our relationships around the country ensure your lawsuit claim will reach an attorney immediately.