Crestor and Rhabdomyolysis Side Effects

An emerging body of research has identified the use of the statin Crestor as a potential risk factor for severe side effects, including rhabdomyolysis, a muscle disease that can lead to kidney damage. Crestor (rosuvastatin), manufactured by AstraZeneca Pharmaceuticals, belongs to a class of drugs called HMG CoA reductase inhibitors, or statins, which are commonly used to reduce cholesterol and triglycerides, a type of fat in the blood. Crestor is also used to reduce the risk of stroke, heart attack and other heart problems in people with diabetes or coronary heart disease. Crestor has been available in the U.S. since 2003 and is currently one of the most popular statin drugs on the market. Unfortunately, recent studies have suggested that the potential side effects of Crestor may actually outweigh any cholesterol-lowering benefits of the drug. If you took Crestor and have since suffered from one or more serious side effects, contact a Crestor attorney to discuss your options for legal recourse.

Rhabdomyolysis Symptoms

Rhabdomyolysis is the breakdown of muscle fibers which results in the release of muscle fiber contents, called myoglobin, into the bloodstream. Some of these muscle fiber contents are harmful to the kidney and commonly cause significant kidney damage. Dead muscle tissue may also cause a large amount of fluid to move from the blood into the muscle, potentially leading to shock and reduced blood flow to the kidneys. Common symptoms of rhabdomyolysis include:

  • Muscle stiffness or aching
  • Abnormal urine color
  • Weakness of the affected muscles
  • Muscle tenderness

Other rhabdomyolysis symptoms may include joint pain, fatigue, weight gain and even seizures.

Rhabdomyolysis Treatment and Prognosis

If rhabdomyolysis is diagnosed quickly and treated with aggressive hydration, kidney damage can be avoided by rapidly flushing myoglobin out of the kidneys. Depending on the severity of the disease, some patients may require kidney dialysis. The prognosis for patients with rhabdomyolysis depends largely on the extent of kidney damage; more serious cases of rhabdomyolysis may result in chronic kidney damage. Patients with minor cases of rhabdomyolysis may return to normal activity within a few weeks or months, although some continue to have problems with fatigue and muscle pain. Complications of rhabdomyolysis may include acute renal failure and acute tubular necrosis.

Crestor Side Effect Studies and FDA Warnings

The FDA issued a public health advisory in 2005 warning patients and physicians about the risk of rhabdomyolysis and kidney failure in patients taking statin drugs like Crestor. This FDA warning required AstraZeneca to update the Crestor warning label to include the risk of increased muscle toxicity potentially linked to Crestor, and the possible adverse effects on the kidneys. According to researchers at the Tufts-New England Medical Center, Crestor had the poorest safety profile of the three most commonly prescribed statin medications on the market. The most severe side effects allegedly associated with Crestor were muscle damage (rhabdomyolysis) and kidney damage, which frequently required hospitalization. In light of the severity of potential Crestor side effects, these researchers recommended that healthcare professionals consider other statins besides Crestor as first-line therapy for elevated cholesterol.

Crestor Attorneys for Rhabdomyolysis Side Effects

Rhabdomyolysis is an extremely dangerous disease which can lead to acute kidney damage and possibly even chronic kidney failure. If you or a loved one has suffered from a rhabdomyolysis side effect, and you believe Crestor to be the cause, contact a Crestor attorney to discuss your legal options. You may be entitled to financial compensation for your injuries, medical expenses, and pain and suffering, which you can collect by filing a Crestor lawsuit against AstraZeneca Pharmaceuticals. The main goal of Crestor attorneys is to help victims of potential Crestor side effects protect their rights and hold the allegedly negligent drug company liable for their injuries. Too often, victims of pharmaceutical drug-related injuries are taken advantage of during their time of need, by deceptive drug companies and sometimes even insurance companies. By hiring an experienced Crestor lawyer to represent your case, you can collect the compensation you deserve and protect yourself and your family from further harm.

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