Recent warnings issued by the FDA alert patients and healthcare professionals that the popular diabetes drug Actos side effects may increase the risk of bladder cancer when used for more than a year. Actos is a prescription medication used to help control blood sugar levels in individuals with Type 2 diabetes. The active ingredient in Actos is pioglitazone hydrochloride, which belongs to a class of drugs known as thiazolidinediones. Actos helps lower blood glucose levels by increasing the sensitivity of liver, fat and muscle cells to insulin, allowing cells to remove glucose from the blood more effectively. Actos was approved by the FDA in 1999 as a medication to be used in combination with diet and exercise to treat Type 2 diabetes in adults. Actos is currently manufactured by pharmaceutical company, Takeda Pharmaceuticals North America, Inc.
As new research focuses on the potential side effects of diabetes drugs like Actos, serious concerns about the safety of these drugs have been raised by physicians and patients across the country. The recent FDA warning comes just a few days after Actos was removed from the market in Germany and France per concerns about an increased risk of bladder cancer side effects among Actos users. The only other thiazolidinedione, Avandia (rosiglitazone), was taken off the U.S. market just last month because it was linked to an increased risk of serious cardiovascular risks, including heart disease and possible heart failure. The FDA will require a new warning concerning the side effects of increased risk of bladder cancer to be added to the Actos label.
In 2010, more than two million patients were taking anti-diabetic drugs like Actos (pioglitazone), metformin and glimepiride. The most recent study regarding potential Actos side effects is an ongoing ten-year epidemiological study designed to evaluate whether Actos is associated with an increased risk of bladder cancer side effects. Actos manufacturer, Takeda, has conducted an analysis of the study data at the five-year mark and their results were then reviewed by the FDA. According to the analysis, an increased risk of bladder cancer was observed among individuals with the longest exposure to Actos, as well as those exposed to the highest cumulative dose of Actos. In one study involving more than 193,000 patients with diabetes, a duration of Actos therapy longer than 12 months was associated with side effects of a forty percent increased risk for bladder cancer. In addition, the French study which ultimately led to Actos being removed from the French market found that the risk of bladder cancer side effects in Actos patients was dose-dependent and rose as time spent taking Actos lengthened past one year.
Bladder cancer affects approximately twenty out of 100,000 people per year in the United States, and the risk is believed to be higher in diabetics. The FDA has advised physicians to avoid prescribing Actos to patients with bladder cancer and to use the drug with caution in patients who have had bladder cancer in the past. The FDA also urges patients and healthcare professionals to consider all benefits and risks of Actos treatment before making any decisions to begin or continue use of the drug. In the meantime, the FDA will continue to review information related to the Actos safety concern and will update the public when additional information is available. According to the FDA, if you are currently taking Actos, you should not discontinue use of the drug without first consulting your healthcare provider.
Actos may be associated with an increased risk of major side effects among patients, particularly bladder cancer. If you or a loved one has suffered from bladder cancer, which you believe to be associated with Actos side effects, contact an Actos attorney, as you may have grounds to file an Actos lawsuit or Actos class action lawsuit against Takeda Pharmaceuticals. Bladder cancer is an extremely serious side effect and should be taken into consideration when determining whether or not Actos is the right medication for you. By hiring an Actos lawyer to represent your case, you can seek financial compensation for your injuries, the medical expenses resulting from treating your injuries, and the pain and suffering incurred by you and your family because of Actos side effects. Drug companies like Takeda are responsible for the safety of their medications even after they enter the market, and should be held accountable for any injuries sustained by consumers of their products. Unfortunately, this isn't always the case. With the help of an Actos attorney, victims of potential Actos side effects can stand up to Takeda and protect themselves from further harm.
Side Effects RX is an informational website that educates consumers on side effects that could have been caused by drugs and medical devices. This website has no relationship with any of the aforementioned drugs, pharmaceutical companies or medical device companies. SideEffectsRx.com was not written by medical professionals and should not be mistaken for medical advice. The purpose of this site is to inform consumers of the potential for side effects in certain drugs and medical devices. *This is a Consumer Justice Foundation website. We are not attorneys. Our relationships around the country ensure your lawsuit claim will reach an attorney immediately.